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Predictive toxicology is one of the newly developed and interdisciplinary study for toxicology in the 21st century, which combines knowledge and tools from such as bioinformatics, in silico modeling and systems biology to predict the safety and health effects of chemical substances to biological systems or the environment. These approaches are also considered as non-animal alternative test methods.

At present, many chemical substances do not have detailed toxicological information. Predictive toxicologic tools or database can be applied to preliminary hazard screening and prioritizing for further toxicological tests. These tools and databases can be also used for understanding the toxic mechanism of chemical substances.

TAAT website will keep collecting and introducing predictive analytics tools and databases which are newly developed and commonly used internationally.

ALTBIB is the Bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing. NLM developed ALTBIB to provide access to PubMed citations for users seeking information on alternatives to animal testing. Many citations provide access to free full text.


CTD is a robust, publicly available database that aims to advance understanding about how environmental exposures affect human health. It provides manually curated information about chemical–gene/protein interactions, chemical–disease and gene–disease relationships. These data are integrated with functional and pathway data to aid in development of hypotheses about the mechanisms underlying environmentally influenced diseases.

Davis AP, Grondin CJ, Johnson RJ, Sciaky D, King BL, McMorran R, Wiegers J, Wiegers TC, Mattingly CJ. The Comparative Toxicogenomics Database: update 2017. Nucleic Acids Res. 2016 Sep 19;[Epub ahead of print] PMID:27651457

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EPA researchers are integrating available chemical information including physicochemical properties, environmental fate and transport, exposure, usage, in vivo toxicity, and in vitro bioassay into an online tool called the Computational Toxicology (CompTox) Chemicals Dashboard, formerly the Chemistry Dashboard, to help decision-makers and scientists quickly and efficiently evaluate thousands of chemicals.

The Dashboard is a one-stop-shop for chemistry, toxicity and exposure information for over 875,000 chemicals. Data and models within the Dashboard also help with efforts to identify chemicals of most need of further testing and reducing the use of animals in chemical testing.

The Dashboard can be searched by chemical identifiers (e.g. DTXSID and CASRN), consumer product categories (i.e. view chemicals found in certain product types), and assays/genes associated with high-throughput screening data. Using high-throughput screening, living cells or proteins are exposed to chemicals and examined for subsequent changes that suggest potential biological responses.

Reference:What is the CompTox Chemicals Dashboard?
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EURL ECVAM Database on Alternative Methods to Animal Experimentation (DB-ALM) is a publicly accessible collection of alternative method summaries and protocols.

It focuses primarily on methods submitted to EURL ECVAM for validation, and those identified in ad hoc reviews of the literature and end-users in specific application areas between 2000 and 2019.

All method summaries and protocols can be searched in a web interface and then retrieved individually, but they can also be downloaded for flexible perusal on a local PC. Search criteria include topic areas, biological endpoints, experimental systems, and others.

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OpenFoodTox is a structured database summarising the outcomes of hazard identification and characterisation for the human health (all regulated products and contaminants), the animal health (feed additives, pesticides and contaminants) and the environment (feed additives and pesticides).

OpenFoodTox provides information on the substance characterisation, the links to EFSA’s related output, background European legislation, and a summary of the critical toxicological endpoints and reference values.

The data model of OpenFoodTox has been designed using OECD Harmonised Template (OHTs) as a basis to collect and structure the data in a harmonised manner. OpenFoodTox provides open source data for the substance characterisation, EFSA outputs, reference points, reference values and genotoxicity.

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Globally Harmonized System of Classification and Labelling of Chemicals (GHS) addresses classification of chemicals by types of hazard and proposes harmonized hazard communication elements, including labels and safety data sheets. It aims at ensuring that information on physical hazards and toxicity from chemicals be available in order to enhance the protection of human health and the environment during the handling, transport and use of these chemicals. The GHS also provides a basis for harmonization of rules and regulations on chemicals at national, regional and worldwide level, an important factor also for trade facilitation.

GHS (Rev.8) (2019):PDF
GHS (Rev.7) (2017):PDF
GHS in Taiwan

The NAT database is a unique tool currently containing 250 entries on animal-free methods and will continuously be updated. The NAT database is freely available for everyone and the entries are free for download and sharing. With the help of this database everyone can obtain information on innovative research technologies not harming animals for science.

Reference:NAT Database on non-animal technologies
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eChemPortal allows simultaneous searching of reports and datasets by chemical name and number, by chemical property, and by GHS classification. Direct links to collections of chemical hazard and risk information prepared for government chemical review programmes at national, regional and international levels are obtained. Classification results according to national/regional hazard classification schemes or to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) are provided when available. In addition, eChemPortal provides also exposure and use information on chemicals.

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The OECD Guidelines for the Testing of Chemicals are a unique tool for assessing the potential effects of chemicals on human health and the environment. They are split into five sections: Section 1: Physical-Chemical properties; Section 2: Effects on Biotic Systems; Section 3:Environmental fate and behaviour; Section 4: Health Effects and Section 5: Other Test Guidelines. Accepted internationally as standard methods for safety testing, the Guidelines are used by professionals in industry, academia and government involved in the testing and assessment of chemicals (industrial chemicals, pesticides, personal care products, etc.). These Guidelines are continuously expanded and updated to ensure they reflect the state-of-the-art science and techniques to meet member countries regulatory needs. The Guidelines are elaborated with the assistance of experts from regulatory agencies, academia, industry, environmental and animal welfare organisations. OECD Test Guidelines are covered by the OECD Mutual Acceptance of Data (MAD) system. Under this system, laboratory test results related to the safety of chemicals that are generated in accordance with OECD Test Guidelines and OECD Principles of Good Laboratory Practices are accepted in all OECD countries and adherent countries for the purpose of safety assessment and other uses relating to the protection of human health and the environment.

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TSAR tracks the progress of alternative, non-animal methods, for testing chemicals or biological agents such as vaccines towards acceptance as a recognised test method for use in various sectors

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