Introduction of Alternatives

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Traditionally, the safety assessments of chemical substances and related products mostly relied on using laboratory animals for in vivo tests. However, the animal welfare and ethics usage have been highly concerned in recent years. In addition, the human-relevance has become an issue. The time and the cost for animal testing are still high, and the regulatory requirements are needed to be met. All these reasons result in the development of non-animal alternatives (or new approach methodologies), and it becomes a world trend.

Many non-animal alternatives and testing strategies have been developed and used internationally, including in chemico test, in vitro assays, in silico modeling and prediction. Some alternative test methods have been validated and adopted by governmental agencies of some countries, and used by related industry such as manufacturing and testing companies. For now, the validated non-animal alternatives on skin irritation/corrosion, eye serios damage/irritation, skin sensitisation and drug pyrogen screening tests have been commonly used. In addition, other new alternative methods are being actively developed, such as microfluidics, organ-on-chips (Oocs), microphysicological system (MPS), 3-D printing and culture, tissue engineering such as organoids and embryoids as well as computational modeling and predictive analytic tools...etc.

TAAT website will keep collecting and introducing the non-animal alternatives which are newly developed and commonly used internationally.